3-AMINO-4-METHYLAMINO-BENZOIC ACID manufacturers
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| | 3-AMINO-4-METHYLAMINO-BENZOIC ACID Basic information |
| Product Name: | 3-AMINO-4-METHYLAMINO-BENZOIC ACID | | Synonyms: | RARECHEM AL BO 1003;3-AMINO-4-METHYLAMINO-BENZOIC ACID;Benzoic acid, 3-aMino-4-(MethylaMino)-;3-Amino-4-(methylamino);Dabigatran Impurity 52;Dabigatran carbyne Impurity 28 | | CAS: | 66315-15-9 | | MF: | C8H10N2O2 | | MW: | 166.18 | | EINECS: | | | Product Categories: | | | Mol File: | 66315-15-9.mol |  |
| | 3-AMINO-4-METHYLAMINO-BENZOIC ACID Chemical Properties |
| Boiling point | 386.0±37.0 °C(Predicted) | | density | 1.343±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 4.04±0.10(Predicted) | | Appearance | Brown to black Solid |
| | 3-AMINO-4-METHYLAMINO-BENZOIC ACID Usage And Synthesis |
| Synthesis | Step 2. 4-(Methylamino)-3-nitrobenzoic acid (9.8 g, 49.96 mmol) and palladium-carbon catalyst (1 g) were suspended in methanol (200 ml), and the reaction was stirred for 2 hours at room temperature and under hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford 3-amino-4-(methylamino)benzoic acid (8.2 g, 99% yield) as a white solid. The product was confirmed by LC-MS (electrospray ionization, m/z): [M + H]+ 167.11. 1H-NMR (300 MHz, DMSO-d6) δ 7.47-7.51 (m, 1H), 7.37 (d, J = 2.1Hz, 1H), 6.53 (d, J = 8.4Hz, 1H), 2.90 (s, 3H). | | References | [1] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 41
[2] Tetrahedron Letters, 2017, vol. 58, # 43, p. 4145 - 4148
[3] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0292
[4] Chem.Abstr., 1978, vol. 89, # 61044,
[5] Patent: WO2004/26829, 2004, A2. Location in patent: Page/Page column 77 |
| | 3-AMINO-4-METHYLAMINO-BENZOIC ACID Preparation Products And Raw materials |
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