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| | 1,2-Dibromo-4,5-difluorobenzene Basic information |
| Product Name: | 1,2-Dibromo-4,5-difluorobenzene | | Synonyms: | Benzene, 1,2-dibromo-4,5-difluoro-;1,2-Dibromo-4,5-difluorobenzene 98%;1,2-Dibromo-4,5-difluorobenzene98%;1,2-DIBROMO-4,5-DIFLUOROBENZENE;1,2-Dibromo-4,5-difluorobenzene,99%;1,2-Dibromo-4,5-difl;1,2-DibroMo-4,5-2-fluorobenzene;1,2-Dibromo-4,5-difluorobenzene> | | CAS: | 64695-78-9 | | MF: | C6H2Br2F2 | | MW: | 271.88 | | EINECS: | 265-021-1 | | Product Categories: | Aromatic Halides (substituted);Bromine Compounds;Fluorine Compounds;Aryl;Halogenated Hydrocarbons;C6 | | Mol File: | 64695-78-9.mol |  |
| | 1,2-Dibromo-4,5-difluorobenzene Chemical Properties |
| Melting point | 33-35 °C (lit.) | | Boiling point | 216.2±35.0 °C(Predicted) | | density | 2.1030 (rough estimate) | | refractive index | 1.5151 (estimate) | | Fp | 112 °F | | storage temp. | Sealed in dry,Room Temperature | | form | powder to lump to clear liquid | | color | White or Colorless to Light yellow | | Water Solubility | insoluble | | BRN | 1941132 | | InChI | InChI=1S/C6H2Br2F2/c7-3-1-5(9)6(10)2-4(3)8/h1-2H | | InChIKey | JTEZQWOKRHOKDG-UHFFFAOYSA-N | | SMILES | C1(Br)=CC(F)=C(F)C=C1Br | | CAS DataBase Reference | 64695-78-9(CAS DataBase Reference) | | NIST Chemistry Reference | 1,2-Dibromo-4,5-difluorobenzene(64695-78-9) |
| Hazard Codes | Xi | | Risk Statements | 10-36/37/38 | | Safety Statements | 16-26-36/37/39-24/25 | | RIDADR | UN 1325 4.1/PG 2 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 4.1 | | PackingGroup | III | | HS Code | 29039990 | | Storage Class | 4.1B - Flammable solid hazardous materials | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | 1,2-Dibromo-4,5-difluorobenzene Usage And Synthesis |
| Chemical Properties | white crystalline low melting mass | | Uses | 1,2-Dibromo-4,5-difluorobenzene has been used in the preparation of:
- 2,2′-dibromo-4,4′,5,5′-tetrafluorobiphenyl
- 2-(2,3-dibromo-5,6-difluorophenyl)propan-2-ol
| | Synthesis | General procedure for the synthesis of 1,2-dibromo-4,5-difluorobenzene from 1,2-difluorobenzene: First, 84 mg (1.5 mmol) of iron powder was homogeneously dispersed in 7.53 g (50 mmol) of 1,2-difluorobenzene and the temperature of the reaction system was adjusted to 20 °C. Subsequently, 18.4 g (115 mmol) of bromine was slowly added dropwise over a period of 50 min, during which the reaction temperature was maintained at about 20 °C. Upon completion of the dropwise addition, the reaction temperature was raised to 40 °C for 2 hours, followed by further raising the temperature to 50 °C to continue the reaction for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into an aqueous solution prepared from 25.2 g of sodium bicarbonate and 12.6 g of sodium sulfite dissolved in 100 mL of water. The reaction product was extracted with ethyl acetate and the organic phase was washed sequentially with water and saturated brine solution, followed by drying with magnesium sulfate. After filtration to remove the desiccant, the reaction was quantified by HPLC, which showed 94% yield of 1,2-dibromo-4,5-difluorobenzene. | | References | [1] Patent: EP2940002, 2015, A1. Location in patent: Paragraph 0051; 0052
[2] Collection of Czechoslovak Chemical Communications, 1977, vol. 42, # 6, p. 2001 - 2017 |
| | 1,2-Dibromo-4,5-difluorobenzene Preparation Products And Raw materials |
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