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| | 2-[[4-(2-Methoxyphenyl)piperazin-1-yl] methyl]-6-methyl-2,3-dihydroimidazo[1,2c]quinazolin-5(6H)-one Basic information |
| | 2-[[4-(2-Methoxyphenyl)piperazin-1-yl] methyl]-6-methyl-2,3-dihydroimidazo[1,2c]quinazolin-5(6H)-one Chemical Properties |
| storage temp. | Store at RT | | solubility | <20.27mg/ml in DMSO | | form | Powder |
| | 2-[[4-(2-Methoxyphenyl)piperazin-1-yl] methyl]-6-methyl-2,3-dihydroimidazo[1,2c]quinazolin-5(6H)-one Usage And Synthesis |
| Uses | 2-MPMDQ is a novel class of α1-adrenoceptor antagonists and acts as an anti-hypertensive agent. | | Definition | ChEBI: 2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-6-methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5-one is a member of piperazines. | | Biological Activity | Potent and selective α 1 -adrenoceptor antagonist; hypotensive. | | IC 50 | α1-adrenergic receptor: 0.37 nM (Ki); α2-adrenergic receptor: 1740 nM (Ki) | | references | [1]. chern jw, tao pl, yen mh, et al. studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. j med chem, 1993, 36(15): 2196-2207. |
| | 2-[[4-(2-Methoxyphenyl)piperazin-1-yl] methyl]-6-methyl-2,3-dihydroimidazo[1,2c]quinazolin-5(6H)-one Preparation Products And Raw materials |
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