(4-AMINO-3-METHOXYPHENYL)METHANOL manufacturers
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| (4-AMINO-3-METHOXYPHENYL)METHANOL Basic information |
Product Name: | (4-AMINO-3-METHOXYPHENYL)METHANOL | Synonyms: | (4-AMINO-3-METHOXYPHENYL)METHANOL;[4-Amino-3-(methyloxy)phenyl]methanol;BenzeneMethanol,4-aMino-3-Methoxy-;4-Amino-3-methoxy-benzenemethanol;4-Amino-3-methoxybenzyl Alcohol | CAS: | 148459-54-5 | MF: | C8H11NO2 | MW: | 153.18 | EINECS: | | Product Categories: | | Mol File: | 148459-54-5.mol |  |
| (4-AMINO-3-METHOXYPHENYL)METHANOL Chemical Properties |
Boiling point | 312℃ | density | 1.182 | Fp | 142℃ | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | Appearance | Light brown to yellow Liquid | InChI | InChI=1S/C8H11NO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-4,10H,5,9H2,1H3 | InChIKey | RVYSKGNWKIIUIF-UHFFFAOYSA-N | SMILES | C1(CO)=CC=C(N)C(OC)=C1 |
| (4-AMINO-3-METHOXYPHENYL)METHANOL Usage And Synthesis |
Uses | (4-Amino-3-methoxyphenyl)methanol is a key intermediate in cyclotriveratrylene chemistry. | Synthesis | 3-Methoxy-4-nitrobenzyl alcohol (5 g, 27 mmol) was used as starting material, which was dissolved in methanol (250 mL) and subsequently transferred to a reaction flask containing 10% Pd-C catalyst (5 mol%). The reaction mixture was stirred and reacted overnight under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth plug and the filtrate was concentrated. The crude product was purified by silica gel column chromatography using EtOAc/hexane as eluent to give the final 4-amino-3-methoxybenzyl alcohol as a colorless oil (0.5 g, 15% yield). | References | [1] Bulletin de la Societe Chimique de France, 1993, vol. 130, # 1, p. 93 - 95 [2] Patent: WO2005/97752, 2005, A1. Location in patent: Page/Page column 124-125 [3] Tetrahedron, 2004, vol. 60, # 19, p. 4295 - 4302 [4] Patent: US5994368, 1999, A [5] Patent: US6008229, 1999, A |
| (4-AMINO-3-METHOXYPHENYL)METHANOL Preparation Products And Raw materials |
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