- Dimethomorph
-
- $0.00 / 1kg
-
2026-01-24
- CAS:110488-70-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: Customise
- Dimethomorph
-
- $1000.00 / 1kg
-
2026-01-21
- CAS:110488-70-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000
- Dimethomorph
-
- $10.00 / 1KG
-
2026-01-05
- CAS:110488-70-5
- Min. Order: 1KG
- Purity: 80%
- Supply Ability: 10 mt
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| Product Name: | Dimethomorph | | Synonyms: | 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)-morpholin (e,z)-4-[3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]morpholine (e,z)-4-[3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)morpholine;Dimethomorph W.P.(50%);Festival C;Dimethomorph 100mg [110488-70-5];3-(4-Chlorophenyl)-3-(3,4-diMethoxyphenyl)-1-(4-Morpholinyl)-2-propen-1-one;3-(4-Chlorophenyl)-3-(3,4-diMethoxyphenyl)-1-Morpholinoprop-2-en-1-one;Dimethomorph 0;Factory hot sell Dimethomorph CAS:110488-70-5 with best price | | CAS: | 110488-70-5 | | MF: | C21H22ClNO4 | | MW: | 387.86 | | EINECS: | 404-200-2 | | Product Categories: | Agro-Products;Aromatics;Heterocycles;INSECTICIDE;Pesticides&Metabolites;Morpholines;Fungicides;DID - DINPesticides;DAlphabetic;D;Alpha sort | | Mol File: | 110488-70-5.mol |  |
| | Dimethomorph Chemical Properties |
| Melting point | 125-149°C | | Boiling point | 584.9±50.0 °C(Predicted) | | density | 1.231±0.06 g/cm3(Predicted) | | vapor pressure | 1 x 10-6 Pa (25 °C) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform: Soluble,Methanol: Soluble | | pka | -1.19±0.20(Predicted) | | form | Solid | | Water Solubility | 50 mg l-1 (20-23 °C) | | color | White to off-white | | Merck | 13,3248 | | BRN | 8794474 | | Major Application | agriculture
environmental | | InChI | 1S/C21H22ClNO4/c1-25-19-8-5-16(13-20(19)26-2)18(15-3-6-17(22)7-4-15)14-21(24)23-9-11-27-12-10-23/h3-8,13-14H,9-12H2,1-2H3/b18-14+ | | InChIKey | QNBTYORWCCMPQP-NBVRZTHBSA-N | | SMILES | COc1ccc(cc1OC)\C(=C\C(=O)N2CCOCC2)c3ccc(Cl)cc3 | | LogP | 2.680 | | EPA Substance Registry System | Dimethomorph (110488-70-5) |
| Hazard Codes | N | | Risk Statements | 51/53 | | Safety Statements | 61 | | RIDADR | UN3077 9/PG 3 | | WGK Germany | 2 | | RTECS | QE0478300 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Aquatic Chronic 2
Repr. 1B | | Hazardous Substances Data | 110488-70-5(Hazardous Substances Data) | | Toxicity | LD50 in rats (mg/kg): 321 i.p.; 3900 orally; >5000 dermally; LC50 (4-hr inhalation): >4.2 mg/ml (Veenstra, Owen) |
| | Dimethomorph Usage And Synthesis |
| Description | Dimethomorph is a cinnamic acid derivative and a member of the morpholine chemical family. Dimethomorph is a mixture of E- and Z-isomers in the ratio of about 1:1 and only the Z-isomer has the fungicidal activity. It fungicidal activity works by the inhibition of sterol (ergosterol) synthesis.
Dimethomorph is a systemic fungicide to protect against various fungal pathogens in vines and other crops. Dimethomorph is used to against downy mildews, late blights, anthracnose, septoria leaf spot, crown rot, and root rot for curbubits, grapevines, head lettuce, onions, potatoes, tomatoes, and fruit including blackberries, raspberries, strawberries.
| | References | [1] http://www.fao.org
[2] http://pmep.cce.cornell.edu
[3] http://sitem.herts.ac.uk/aeru/ppdb/en/Reports/245.htm
| | Description | Dimethomorph is a morpholine fungicide that inhibits fungal cell wall formation. It inhibits mycelial growth of the oomycete fungi P. citrophthora, P. parasitica, P. capsici, and P. infestans (EC50s = 0.14, 0.38, <0.1, and 0.16-0.3 μg/ml, respectively) but is less active against the green algae species C. vulgaris or S. obliquus in vitro (EC50s = 47.46 and 44.87 μg/ml, respectively). It inhibits androgen receptor (AR) activity in a reporter assay in MDA-kb2 human breast cancer cells but not in a yeast antiandrogen screen (IC20s = 0.263 and 38.5 μM, respectively). It is not toxic to rats (LD50 = 3,900 mg/kg) or goldfish (C. auratus; LC50 = >32 μg/ml). | | Chemical Properties | Off-White Solid | | Uses | Dimethomorph is a systemic fungicide which exhibits protectant,
curative and antisporulant activities. It is active against fungal diseases
such as leaf blight, downy mildew, damping off and foot-rot caused by
Phytophthora spp. in/on grapes, potatoes and tomatoes. | | Uses | Agricultural fungicide. | | Definition | ChEBI: A mixture of (E)- and (Z)-dimethomorph in an unspecified ratio. It is used as a systemic fungicide used on vines, potatoes, and greenhouse crops; only the Z isomer has fungicidal activity. | | Agricultural Uses | Fungicide: A systemic fungicide that protects crops from mold.
It also kills mold and prevents their spread; controls late
blight on tomatoes; and is used as a wood preservative to
control downey mildew. | | Trade name | ACROBAT® WP; FORUM DC®, [manco-
zeb + dimethomorph]; CME 151®; STATURE® | | Synthesis | The first step: xylene and acetic anhydride at room temperature stirring drop of morpholine, drop the end of the slow increase in temperature to 110 ??, reflux insulation 5h, after the end of the over into the distillation kettle desolvation and by-products of acetic acid, the kettle residual part for the intermediate acetyl morpholine
The residual part in the kettle is the intermediate acetylmorpholine, the content is more than or equal to 99%, the yield is more than or equal to 90.2%.
The second step: in the reaction kettle into xylene, E-phenyl ketone and amino sodium, stirring temperature to 100 ?? when adding acetomorpholine drops, droplet finished temperature to 110 ?? reflux insulation 2h, insulation end of the temperature to 80 ?? over the wash kettle divided into
Out of the waste lye, after washing to neutral water into the distillation kettle recovery of xylene, centrifugal drying enoymorpholine, content greater than or equal to 95%, yield greater than or equal to 76.6%.
In this method, sodium amide is used to replace sodium tert-butoxide in traditional technology, which greatly improves the reaction speed, shortens the reaction time from 10h to 2h, and greatly improves the production efficiency. | | Metabolic pathway | Limited data are available in the open literature. Information presented in
this summary is abstracted from the data evaluation published by the
Pesticide Safety Directorate (PSD, 1994). Dimethomorph is a (1:l) mixture
of the E- and Z-isomers. The Z-isomer has been shown to have all the
intrinsic biological activities. The isomerisation of the E- and Z-isomers
was observed when resolved isomers were exposed to UV light. Dimethomorph
undergoes extensive degradation and metabolism in soil,
plants and animals. The major metabolic pathway is the O-demethylation
of one of the phenolic methoxy moieties to the corresponding phenols
and conjugates. Other metabolic reactions include the oxidation of one of
the CH2 moieties of the morpholine ring and the cleavage/opening of
the morpholine ring (Scheme 1). | | Degradation | Dimethomorph (1) is hydrolytically stable with no observable degradation
in pH 4-9 buffered solutions at 70-90 °C for up to 10 weeks.
Degradation occurred when dimethomorph in pH 5 buffer solution was
irradiated under Hanau Suntest apparatus (<290 nm) at 25 °C. The calculated
aqueous photolytic degradation half-life (DT50) was ca. 25-28 days of
continuous irradiation, No sigruficant degradation product (>7% of the
applied radioactivity) was identified. | | References | [1] (EFSA) E F S A. Conclusion regarding the peer review of the pesticide risk assessment of the active substance dimethoate[C]//4 7. 2006. DOI: 10.2903/j.efsa.2006.84r
[2] M E MATHERON M P. Impact of Azoxystrobin, Dimethomorph, Fluazinam, Fosetyl-Al, and Metalaxyl on Growth, Sporulation, and Zoospore Cyst Germination of Three Phytophthora spp.[J]. Plant disease, 2000, 84 4: 454-458. DOI: 10.1094/pdis.2000.84.4.454
[3] XIAO-BO YU. Aquatic environmental safety assessment and inhibition mechanism of chemicals for targeting Microcystis aeruginosa.[J]. Ecotoxicology, 2014, 23 9: 1638-1647. DOI: 10.1007/s10646-014-1303-x |
| | Dimethomorph Preparation Products And Raw materials |
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