- IDO1-IN-1
-
- $29.00 / 1mL
-
2026-01-26
- CAS:615-21-4
- Min. Order:
- Purity: 99.61%
- Supply Ability: 10g
|
| | 2-HYDRAZINOBENZOTHIAZOLE Basic information |
| | 2-HYDRAZINOBENZOTHIAZOLE Chemical Properties |
| Melting point | 198-202 °C (lit.) | | Boiling point | 352.4±25.0 °C(Predicted) | | density | 1.2404 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | Solubility in hot methanol almost transparent. | | pka | 2.81±0.20(Predicted) | | form | powder to crystal | | color | White to Light yellow to Light orange | | InChI | InChI=1S/C7H7N3S/c8-10-7-9-5-3-1-2-4-6(5)11-7/h1-4H,8H2,(H,9,10) | | InChIKey | JYSUYJCLUODSLN-UHFFFAOYSA-N | | SMILES | S1C2=CC=CC=C2N=C1NN | | CAS DataBase Reference | 615-21-4(CAS DataBase Reference) | | EPA Substance Registry System | 2(3H)-Benzothiazolone, hydrazone (615-21-4) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/38 | | Safety Statements | 26-36 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | DL4725000 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | PackingGroup | III | | HS Code | 29342000 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2 |
| | 2-HYDRAZINOBENZOTHIAZOLE Usage And Synthesis |
| Chemical Properties | slightly yellow to beige-green crystalline powder | | Uses | It is employed in the spectrophotometric analysis determination of methenamine and its salts. It is also used in the detection and repair mechanism of Etheno-DNA adducts. | | Synthesis | General procedure for the synthesis of 2-hydrazinobenzothiazole from 2-aminobenzothiazole: Hydrazine hydrate (1 equiv.) was dissolved in ethylene glycol at 5 °C. Under stirring, concentrated hydrochloric acid (2 mL) was added slowly and dropwise, followed by 2-aminobenzothiazole (1 eq.). The reaction mixture was heated to reflux for 2-3 hours, after which it was cooled to room temperature. Upon completion of the reaction, the solid product formed was collected by filtration, washed with water and purified by recrystallization from ethanol to afford the target compound 2-hydrazinobenzo[d]thiazole (32). The product was white crystals in 90% yield with a melting point ranging from 200 °C to 202 °C. 1H NMR (DMSO-d6, 400 MHz) data were as follows: δ 4.84 (2H, s), 6.85-7.65 (4H, m), 8.62 (1H, s). ESI-MS (m/z) analysis showed the molecular ion peak as 166 (MH+). | | References | [1] Helvetica Chimica Acta, 1980, vol. 63, # 3, p. 682 - 692
[2] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 418 - 428
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[4] Medicinal Chemistry Research, 2012, vol. 21, # 9, p. 2428 - 2442
[5] Journal of Molecular Structure, 2014, vol. 1060, # 1, p. 215 - 222 |
| | 2-HYDRAZINOBENZOTHIAZOLE Preparation Products And Raw materials |
|