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| | 2-Bromo-3-fluoronitrobenzene Basic information |
| | 2-Bromo-3-fluoronitrobenzene Chemical Properties |
| Melting point | 42.0-44.0 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | | Boiling point | 222.3±20.0 °C(Predicted) | | density | 1.808±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | color | yellow | | CAS DataBase Reference | 59255-94-6(CAS DataBase Reference) |
| Hazard Codes | T | | HazardClass | IRRITANT | | HS Code | 2904990090 |
| | 2-Bromo-3-fluoronitrobenzene Usage And Synthesis |
| Synthesis | Preparation method of 2-bromo-3-fluoronitrobenzene: Add 21.6g (0.1mol) 2-bromo-3-nitroaniline, 12.5ml (0.15mol) concentrated hydrochloric acid, and 12.5ml water into a reaction bottle, and reduce the temperature to 15°C; dissolve 8.3g (0.12mol) sodium nitrite in 14.5ml water and slowly add dropwise to the above system, then add 11.4g (0.13mol) fluoroboric acid, keep warm at 15°C and stir for 2 hours, track the reaction by HPLC until the reaction of 2-bromo-3-nitroaniline is complete; filter, rinse the filter cake with methanol, and dry to obtain 25.8g of intermediate IV. Add 30 ml of toluene to the reaction flask, heat to 100 ° C, slowly add 10 g (31.7 mmol) of intermediate IV, keep warm and stir for 1 hour, track the reaction by HPLC until the intermediate IV reacts completely: concentrate, recrystallize from ethyl acetate and n-hexane to obtain 5.7 g of 2-Bromo-3-fluoronitrobenzene, with a molar yield of 83%. | | References | [1] Patent: CN108002976, 2018, A. Location in patent: Paragraph 0045; 0047; 0048; 0049; 0058; 0067
[2] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976, vol. 30, p. 141 - 149 |
| | 2-Bromo-3-fluoronitrobenzene Preparation Products And Raw materials |
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