| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
PQM130 manufacturers
- PQM130
-
- $33.00
-
2026-07-15
- CAS:2089415-51-8
- Purity: 99.31%
- Supply Ability: 10g
- PQM130
-
- $33.00
-
2026-07-15
- CAS:2089415-51-8
- Purity: 99.31%
- Supply Ability: 10g
|
| Product Name: | PQM130 | | Synonyms: | PQM130;Inhibitor,PQM-130,Amyloid-β,β-amyloid peptide,Abeta,PQM130,PQM 130,inhibit;2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, [1-(phenylmethyl)-4-piperidinyl]methyl ester, (2E)-;(1-Benzylpiperidin-4-yl)methyl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate;PQM130, 10 mM in DMSO | | CAS: | 2089415-51-8 | | MF: | C23H27NO4 | | MW: | 381.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2089415-51-8.mol |  |
| | PQM130 Chemical Properties |
| Boiling point | 525.3±40.0 °C(Predicted) | | density | 1.174±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.75±0.31(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | PQM130 Usage And Synthesis |
| Description | PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget drug candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD drug development[1].
PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) [1]. Animal Model: Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) [1]. | | Uses | PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget agent candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD agent development[1]. | | in vivo | PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) [1]. | Animal Model: | Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) [1]. | | Dosage: | 0.5 and 1.0 mg/kg. | | Administration: | IP injection daily for 10 days. | | Result: | Ameliorated Aβ1-42O-induced cognitive deficits in mice.
Prevented Aβ1-42O-induced neuronal death in mice.
Antagonized Aβ1-42O-Induced Oxidative Stress in Mice.
Regulated GSK3β and ERK1/2 protein expressions in mice.
Reduced Aβ1-42O-induced astrocytic activation in mice.
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| | References | [1]. Morroni F, et al. PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2019 Jun 12;10:658. |
| | PQM130 Preparation Products And Raw materials |
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