Diketone-PEG4-PFP ester manufacturers
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| | Diketone-PEG4-PFP ester Basic information |
| Product Name: | Diketone-PEG4-PFP ester | | Synonyms: | Diketone-PEG4-PFP ester;4,7,10,13-Tetraoxahexadecanoic acid, 16-[[4-(3,5-dioxohexyl)phenyl]amino]-16-oxo-, 2,3,4,5,6-pentafluorophenyl ester | | CAS: | 2353409-84-2 | | MF: | C30H34F5NO9 | | MW: | 647.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2353409-84-2.mol |  |
| | Diketone-PEG4-PFP ester Chemical Properties |
| Boiling point | 725.7±60.0 °C(Predicted) | | density | 1.314±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | pka | 9.09±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Diketone-PEG4-PFP ester Usage And Synthesis |
| Description | Diketone-PEG4-PFP ester is a PEG linker containing a diketone group and a PFP ester group, an activated ester that reacts with primary amines to form amide bonds. PFP ester has been found to be more stable than other amine reactive groups because it is less likely to undergo hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Diketone-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Diketone-PEG4-PFP ester Preparation Products And Raw materials |
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