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| | Guanosine, 8-methyl-2'-O-methyl- Basic information |
| Product Name: | Guanosine, 8-methyl-2'-O-methyl- | | Synonyms: | Guanosine, 8-methyl-2'-O-methyl-;8-methyl-2'-O-methylguanosine;2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-8-methyl-1H-purin-6-one;2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-8-methyl-3,9-dihydro-6H-purin-6-one;8-Methy-2'-O-Methylguanosine;2′-O-Methyl-8-methyl guanosine | | CAS: | 2306782-64-7 | | MF: | C12H17N5O5 | | MW: | 311.29 | | EINECS: | | | Product Categories: | | | Mol File: | 2306782-64-7.mol |  |
| | Guanosine, 8-methyl-2'-O-methyl- Chemical Properties |
| Boiling point | 691.0±65.0 °C(Predicted) | | density | 1.88±0.1 g/cm3(Predicted) | | pka | 13.22±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | Guanosine, 8-methyl-2'-O-methyl- Usage And Synthesis |
| Uses | 2′-O-Methyl-8-methyl guanosine (m8Gm) is a Z-form RNA stabilizer. 2′-O-Methyl-8-methyl guanosine can markedly stabilize the Z-RNA at low salt conditions[1]. m8Gm-contained oligonucleotides stabilize
the Z-DNA under low salt conditions[2]. | | References | [1] Balasubramaniyam T, Ishizuka T, Xiao CD, Bao HL, Xu Y. 2'-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA. Molecules. 2018;23(10):2572. DOI:10.3390/molecules23102572
[2] Balasubramaniyam T, Ishizuka T, Xu Y. Stability and properties of Z-DNA containing artificial nucleobase 2'-O-methyl-8-methyl guanosine. Bioorg Med Chem. 2019;27(2):364-369. DOI:10.1016/j.bmc.2018.12.005 |
| | Guanosine, 8-methyl-2'-O-methyl- Preparation Products And Raw materials |
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