| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:8-Nitro-cGMP
CAS:913645-39-3
Package:1removed
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| Company Name: |
Enzo Biochem Inc
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| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
| Products Intro: |
Product Name:8-NO2-cGMP
CAS:913645-39-3
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| | Guanosine, 8-nitro-, cyclic 3',5'-(hydrogen phosphate) Basic information |
| | Guanosine, 8-nitro-, cyclic 3',5'-(hydrogen phosphate) Chemical Properties |
| Boiling point | 855.3±75.0 °C(Predicted) | | density | 2.87±0.1 g/cm3(Predicted) | | pka | 0.99±0.60(Predicted) |
| | Guanosine, 8-nitro-, cyclic 3',5'-(hydrogen phosphate) Usage And Synthesis |
| Uses | 8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice[1][2][3][4]. | | Definition | ChEBI: 8-nitroguanosine 3',5'-cyclic monophosphate is a 3',5'-cyclic purine nucleotide that is guanosine 3',5'-cyclic monophosphate in which the hydrogen at position 8 on the purine fragment has been replaced by a nitro group. It has a role as a Brassica napus metabolite, a signalling molecule, a biomarker and a human metabolite. It is a 3',5'-cyclic purine nucleotide and a C-nitro compound. It is functionally related to a 3',5'-cyclic GMP. It is a conjugate acid of an 8-nitroguanosine 3',5'-cyclic monophosphate(1-). | | References | [1] Ihara H, et al. Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells. Chem Res Toxicol. 2017 Sep 18;30(9):1673-1684. DOI:10.1021/acs.chemrestox.7b00120
[2] Tokutomi Y, et al. Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice. Br J Pharmacol. 2011 Apr;162(8):1884-93. DOI:10.1111/j.1476-5381.2011.01201.x
[3] Kaneko K, et al. 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL. Nitric Oxide. 2018 Jan 30;72:46-51. DOI:10.1016/j.niox.2017.11.006
[4] Rawet-Slobodkin M, Elazar Z. 8-nitro-cGMP--a new player in antibacterial autophagy. Mol Cell. 2013 Dec 26;52(6):767-8. DOI:10.1016/j.molcel.2013.12.006 |
| | Guanosine, 8-nitro-, cyclic 3',5'-(hydrogen phosphate) Preparation Products And Raw materials |
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