2-METHYL-4-PIPERIDINONE HYDROCHLORIDE manufacturers
|
| | 2-METHYL-4-PIPERIDINONE HYDROCHLORIDE Basic information | | Uses |
| Product Name: | 2-METHYL-4-PIPERIDINONE HYDROCHLORIDE | | Synonyms: | 2-METHYL-4-PIPERIDINONE HYDROCHLORIDE;2-METHYL-PIPERIDIN-4-ONE HCL;2-methylpiperidin-4-one hydrochloride;2-Methyl-4-piperidone hyd...;2-Methyl-4-piperidone hydrochloride;4-Piperidinone, 2-Methyl-, hydrochloride (1:1);4-Piperidinone, 2-methyl-, hydrochloride;2-Methyl-4-piperidinone, HCl | | CAS: | 13729-77-6 | | MF: | C6H12ClNO | | MW: | 149.61858 | | EINECS: | 200-589-5 | | Product Categories: | | | Mol File: | 13729-77-6.mol |  |
| | 2-METHYL-4-PIPERIDINONE HYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | White to off-white Solid |
| | 2-METHYL-4-PIPERIDINONE HYDROCHLORIDE Usage And Synthesis |
| Uses | 2-Methyl-4-piperidinone hydrochloride can be used as a pharmaceutical synthesis intermediate. | | Synthesis | The amine solution (145 g) was dissolved in THF (200 mL) and added dropwise to a cooled solution of potassium tert-butanolate (58.9 g) in THF (500 mL) over 1 hour. The mixture was stirred at 0C for 2.5 hours and then warmed to room temperature over 1 hour with stirring. An additional 50 mL of 1.0 M potassium tert-butanol in THF was added, and after 1 h, the solvent was removed under vacuum and the residue was dissolved in ethyl acetate (1 L). The organic solution was washed with saturated ammonium chloride (2 x 500 mL) and back-extracted with ethyl acetate (2 x 500 mL). The organic extracts were combined, dried with anhydrous magnesium sulfate, filtered and concentrated in vacuum to give 120.6 g of the crude product, 2-methyl-4-piperidone, as an oil. The oily substance was then treated with 5NHCl (700 mL) at reflux for about 14.5 hours. After cooling, the solution was washed with a mixture of ethyl acetate/ether (1:1, 2 x 300 mL). The aqueous layer was then concentrated to give 2-methyl-4-piperidone hydrochloride. |
| | 2-METHYL-4-PIPERIDINONE HYDROCHLORIDE Preparation Products And Raw materials |
|