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| | 26,27-Dinorcholest-5-ene-3,7,25-triol, 4,4-dimethyl-25,25-di-2-propen-1-yl-, (3β,7β)- Basic information |
| Product Name: | 26,27-Dinorcholest-5-ene-3,7,25-triol, 4,4-dimethyl-25,25-di-2-propen-1-yl-, (3β,7β)- | | Synonyms: | 26,27-Dinorcholest-5-ene-3,7,25-triol, 4,4-dimethyl-25,25-di-2-propen-1-yl-, (3β,7β)-;HMG499 | | CAS: | 2416941-68-7 | | MF: | C33H54O3 | | MW: | 498.79 | | EINECS: | | | Product Categories: | | | Mol File: | 2416941-68-7.mol |  |
| | 26,27-Dinorcholest-5-ene-3,7,25-triol, 4,4-dimethyl-25,25-di-2-propen-1-yl-, (3β,7β)- Chemical Properties |
| Boiling point | 605.6±55.0 °C(Predicted) | | density | 1.05±0.1 g/cm3(Predicted) | | form | Solid | | pka | 14.12±0.70(Predicted) | | color | White to off-white |
| | 26,27-Dinorcholest-5-ene-3,7,25-triol, 4,4-dimethyl-25,25-di-2-propen-1-yl-, (3β,7β)- Usage And Synthesis |
| Uses | HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis[1]. | | References | [1] Jiang SY, et al. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nat Commun. 2018 Dec 3;9(1):5138. DOI:10.1038/s41467-018-07590-3 |
| | 26,27-Dinorcholest-5-ene-3,7,25-triol, 4,4-dimethyl-25,25-di-2-propen-1-yl-, (3β,7β)- Preparation Products And Raw materials |
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Tag:26,27-Dinorcholest-5-ene-3,7,25-triol, 4,4-dimethyl-25,25-di-2-propen-1-yl-, (3β,7β)-(2416941-68-7)
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