1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]-

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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]- Suppliers list
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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]- manufacturers
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]-
Synonyms:1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]-;Thalidomide-?NH-PEG8-OTS;Thalidomide-NH-PEG8-Tos;Pomalidomide-NH-PEG8-Tos;Thalidomide-NH-PEG8-Ts;23-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12,15,18,21-heptaoxatricosan-1-yl 4-methylbenzene-1-sulfonate
CAS:2488761-07-3
MF:C36H49N3O14S
MW:779.85
EINECS:
Product Categories:
Mol File:2488761-07-3.mol
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]- Structure
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]- Chemical Properties
Boiling point 891.4±65.0 °C(Predicted)
density 1.317±0.06 g/cm3(Predicted)
pka10.74±0.40(Predicted)
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]- Usage And Synthesis
UsesThalidomide-NH-PEG8-Ts is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 8-unit PEG linker used in PROTAC technology, such as IDO1 PROTAC degrader (HY-131911)[1].
IC 50Cereblon
References[1] Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953. DOI:10.1016/j.apsb.2020.02.010
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]-(2488761-07-3) Related Product Information
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