2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-

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2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- manufacturers

  • CDK4/6-IN-15
  • CDK4/6-IN-15 pictures
  • $2420.00
  • 2026-07-27
  • CAS:2078047-99-9
  • Purity:
  • Supply Ability: 10g
2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Basic information
Product Name:2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-
Synonyms:2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-;5-(2-((5-(4(dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-5-fluoropyrimidin-4-yl)-N,4- dimethylthiazol-2-amine;CDDD2-94;CDK4/6-IN-15;Butylated hydroxytoluene-d 21
CAS:2078047-99-9
MF:C21H27FN8S
MW:442.56
EINECS:
Product Categories:
Mol File:2078047-99-9.mol
2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Structure
2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Chemical Properties
Boiling point 641.3±65.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
pka9.16±0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Usage And Synthesis
UsesCDK4/6-IN-15 is an orally active and selective CDK4/6 inhibitor. CDK4/6-IN-15 potently inhibits cancer cells growth. CDK4/6-IN-15 arrests cell cycle at G1 phase and suppresses retinoblastoma tumour suppressor protein (Rb) phosphorylation at S780 and E2 factor (E2F)-regulated gene expression[1].
in vivo

CDK4/6-IN-15 (compound 91) (2 mg/kg for i.v. or 10 mg/kg for p.o.; single dose) shows comparable oral absorption in healthy male adult BALB/c mice (20-25 g) as well as (5 mg/kg for i.v. or 200 mg/kg for p.o.; single dose) in male albino Wistar rats (250-350 g)[1].


Pharmacokinetic Analysis[1]

RouteDose (mg/kg)CL (mL/min/kg)Vss (L/kg)AUC (μM·h)Cmax (μM)Tmax (h)t1/2 (h)F (%)
ratIV515527.51.21.4/2.1/
PO20//4.40.34.320.395
mouseIV29015.70.71.3/2.9/
PO10//4.30.62.52.7129
IC 50CDK4: 3 nM (IC50); CDK6: 0.279 μM (IC50); CDK2: 3.335 μM (IC50)
References[1] Tadesse S, et al. Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents. Br J Pharmacol. 2018 Jun;175(12):2399-2413. DOI:10.1111/bph.13974
2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]- Preparation Products And Raw materials
Tag:2-Pyrimidinamine, N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-(2078047-99-9) Related Product Information
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