2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl-

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2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl- Suppliers list
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl- Basic information
Product Name:2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl-
Synonyms:2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl-;JBJ-07-149
CAS:2140807-58-3
MF:C28H26N6O2S
MW:510.61
EINECS:
Product Categories:
Mol File:2140807-58-3.mol
2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl- Structure
2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl- Chemical Properties
density 1.372±0.06 g/cm3(Predicted)
pka7.51±0.50(Predicted)
Safety Information
MSDS Information
2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl- Usage And Synthesis
UsesJBJ-07-149 is an inhibitor for EGFRL858R/T790M with an IC50 of 1.1 nM. JBJ-07-149 inhibits the proliferation of cell Ba/F3 with IC50 of 4.9 μM and 0.148 μM, without and with presence of Cetuximab (HY-P9905). JBJ-07-149 can be used as ligand for target protein in synthesis of DDC-01-163 (HY-139997)[1].
IC 50EGFRL858R/T790M: 1.1 nM (IC50)
References[1] Jang J, et al., Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations. Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14481-14489. DOI:10.1002/anie.202003500
2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl- Preparation Products And Raw materials
Tag:2H-Isoindole-2-acetamide, 1,3-dihydro-1-oxo-α-phenyl-6-[6-(1-piperazinyl)-3-pyridinyl]-N-2-thiazolyl-(2140807-58-3) Related Product Information
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