|
|
| | 3-Chloro-6-ethoxypyridazine Basic information |
| Product Name: | 3-Chloro-6-ethoxypyridazine | | Synonyms: | 3-chloro-6-ethoxypyridazine(SALTDATA: FREE);NSC 94042;Pyridazine, 3-chloro-6-ethoxy-;3-CHLORO-6-ETHOXYPYRIDAZINE ISO 9001：2015 REACH;3-Chloro-6-ethoxypyridazine | | CAS: | 17321-20-9 | | MF: | C6H7ClN2O | | MW: | 158.59 | | EINECS: | | | Product Categories: | | | Mol File: | 17321-20-9.mol |  |
| | 3-Chloro-6-ethoxypyridazine Chemical Properties |
| Melting point | 60-62℃ | | Boiling point | 293.1±20.0 °C(Predicted) | | density | 1.235 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 0.82±0.10(Predicted) | | Appearance | Off-white to yellow Solid |
| | 3-Chloro-6-ethoxypyridazine Usage And Synthesis |
| Synthesis | Potassium carbonate (1.39 g, 10.05 mmol) was added to a 50 mL round-bottomed flask containing 3,6-dichloropyridazine (1.00 g, 6.71 mmol) and anhydrous ethanol (10 mL). The reaction mixture was stirred under ethanol reflux for 22 hours. After completion of the reaction, it was cooled to room temperature, saturated ammonium chloride solution (30 mL) was added and the reaction mixture was extracted with dichloromethane (3 x 30 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was ground with petroleum ether and filtered through a Büchner funnel to give the pure 3-chloro-6-ethoxypyridazine (1.025 g, 97% yield). | | References | [1] Tetrahedron, 2015, vol. 71, # 29, p. 4859 - 4867
[2] Yakugaku Zasshi, 1954, vol. 74, p. 1195,1197
[3] Chem.Abstr., 1955, p. 14768
[4] Yakugaku Zasshi, 1955, vol. 75, p. 778,780
[5] Chem.Abstr., 1956, p. 4970 |
| | 3-Chloro-6-ethoxypyridazine Preparation Products And Raw materials |
|