| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
RO27-3225 TFA manufacturers
- RO27-3225 TFA
-
- $2500.00
-
2026-07-27
- CAS:1373926-49-8
- Purity:
- Supply Ability: 10g
|
| | RO27-3225 TFA Basic information |
| | RO27-3225 TFA Chemical Properties |
| solubility | DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml | | form | Solid | | color | Off-white to light yellow |
| | RO27-3225 TFA Usage And Synthesis |
| Description | RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. | | Uses | RO27-3225 trifluoroacetate is a peptide agonist of melanocortin receptor 4 (MC4R) with neuroprotective and anti-inflammatory activity with an EC50 value of 1 nM, while 8 nM for MC1R. RO27-3225 trifluoroacetate reverses hemorrhagic shock, reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal IL-1β and TNF-α levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation[1][2]. | | IC 50 | MC4R: 1 nM (EC50); MC1R: 8 nM (EC50) | | References | [1] Liu D, et al. Melanocortin MC4 receptor agonists alleviate brain damage in abdominal compartment syndrome in the rat. Neuropeptides. 2015 Feb;49:55-61. DOI:10.1016/j.npep.2014.12.003
[2] Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8. DOI:10.1523/JNEUROSCI.20-09-03442.2000 |
| | RO27-3225 TFA Preparation Products And Raw materials |
|