- L-1-Boc-Nipecotic acid
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- $1.00 / 500g
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2026-01-19
- CAS:88495-54-9
- Min. Order: 300g
- Purity: 99.8%
- Supply Ability: 20 TONS
- L-1-Boc-Nipecotic acid
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- $15.00 / 1KG
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2021-07-02
- CAS:88495-54-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- L-1-Boc-Nipecotic acid
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- $1.00 / 1KG
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2019-07-06
- CAS:88495-54-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000KG
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| | L-1-Boc-Nipecotic acid Basic information |
| Product Name: | L-1-Boc-Nipecotic acid | | Synonyms: | N-T-BUTOXYCARBONYL-DL-3-PIPERIDINECARBOXYLIC ACID;N-T-BUTOXYCARBONYL-DL-NIPECOTIC ACID;N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID;N-T-BUTOXYCARBONYL-(R,S)-NIPECOTIC ACID;N-T-BUTOXYCARBONYL-(R,S)-PIPERIDINE-3-CARBOXYLIC ACID;(S)-1-Boc-Nipecoticacid;(S)-T-BUTYLOXYCARBONYL-NIPECOTIC ACID: (S)-N-T-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID;N-ALPHA-T-BOC-3-CARBOXYPIPERIDINE | | CAS: | 88495-54-9 | | MF: | C11H19NO4 | | MW: | 229.27 | | EINECS: | 100-001-2 | | Product Categories: | piperidine;Piperidines;Chiral Reagent;pharmacetical;chiral | | Mol File: | 88495-54-9.mol |  |
| | L-1-Boc-Nipecotic acid Chemical Properties |
| Melting point | 159-162 °C(lit.) | | Boiling point | 353.2±35.0 °C(Predicted) | | density | 1.164±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 4.49±0.20(Predicted) | | form | solid | | color | White to off-white | | Optical Rotation | [α]22/D +57°, c = 1 in chloroform | | InChI | InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1 | | InChIKey | NXILIHONWRXHFA-QMMMGPOBSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H](C(O)=O)C1 | | CAS DataBase Reference | 88495-54-9(CAS DataBase Reference) |
| Hazard Codes | Xi,N | | Risk Statements | 36/37/38-50 | | Safety Statements | 26-36-61 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Acute 1
Aquatic Chronic 1 |
| | L-1-Boc-Nipecotic acid Usage And Synthesis |
| Chemical Properties | White powder | | Uses | 1-Boc-L-nipecotic acid is used as an organic chemical synthesis intermediate. | | Synthesis | The general procedure for the synthesis of 1-BOC-piperidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-piperidinecarboxylic acid was as follows:
1. To a solution of piperidine-3-carboxylic acid (50.0 g, 387.5 mmol) in tert-butanol (464.0 mL) was slowly added 1N NaOH solution (464.0 mL) at 0 °C and stirred for 10 min.
2. Di-tert-butyl dicarbonate (Boc-anhydride, 143.6 g, 659.0 mmol) was then added.
3. The reaction mixture was stirred continuously at room temperature for 12 hours.
4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and then neutralized to neutrality with 1N HCl solution.
5. The precipitated solid product was collected by filtration and dried to give 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1, 86.0 g, 97% yield) as a white solid.
Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ 1.38 (s, 9H), 1.47 (m, 1H), 1.59 (dt, J = 3.8 Hz, 1H), 1.87 (m, 1H), 2.28 (m, 1H), 2.77-2.84 (dt, J = 2.5,3.0 Hz, 1H), 3.0 (brs. 1H), 3.67 (d, J = 11.0 Hz, 1H), 3.87 (brs, 1H), 12.2 (s, 1H). | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2118 - 2122
[2] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00604
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1719 - 1728
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 966 - 973
[5] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682 |
| | L-1-Boc-Nipecotic acid Preparation Products And Raw materials |
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