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| | Acetyl β-Endorphin (human) (trifluoroacetate salt) Basic information |
| | Acetyl β-Endorphin (human) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Acetyl β-Endorphin (human) (trifluoroacetate salt) Usage And Synthesis |
| Description | Acetyl β-endorphin is an acetylated derivative of β-endorphin that binds to opioid receptors in rat caudal dorsomedial medulla (Ki = 490 nM) and mouse brain membrane preparations (IC50 = 109 nM).1,2 It induces chemotaxis of human monocytes in vitro when used at a concentration of 0.1 nM.3 In vivo, it reduces antinociception in mice induced by β-endorphin (Item Nos. 24153 | 24955), morphine, [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO; Item No. 21553), and [D-Ala2, D-Leu5]-enkephalin (DADLE) in a tail-flick test (ED50s = 2.08, 33.11, 0.03, and 0.07 mol per animal, respectively).2WARNING This product is not for human or veterinary use. | | References | [1] MABEL M D’SOUZA James A C. Characterization of [125I]β-Endorphin Binding Sites in the Rat Caudal Dorsomedial Medulla[J]. Peptides, 1998, 19 5: Pages 931-937. DOI: 10.1016/s0196-9781(98)00024-2
[2] JAVIER GARZÓN Pilar S B. αN-acetyl derivatives of β-endorphin-(1–31) and -(1–27) regulate the supraspinal antinociceptive activity of different opioids in mice[J]. Life sciences, 1991, 48 14: Pages 1417-1427. DOI: 10.1016/0024-3205(91)90439-i
[3] PAOLA SACERDOTE Alberto E P. Analysis of the beta-endorphin structure-related activity on human monocyte chemotaxis: Importance of the N- and C-terminal[J]. Peptides, 1989, 10 3: Pages 565-569. DOI: 10.1016/0196-9781(89)90143-5 |
| | Acetyl β-Endorphin (human) (trifluoroacetate salt) Preparation Products And Raw materials |
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