7-chloro-1H-indole-2-carboxylic acid

7-chloro-1H-indole-2-carboxylic acid Suppliers list

Company Name:	SHANDONG OUCHEM CO.,LTD.
Tel:	+86-18506360988
Email:	wtaili@ouchem.cn
Products Intro:	Product Name:7-chloro-1H-indole-2-carboxylic acid CAS:28899-75-4 Purity:98% Min. Package:01kg;\|1kg;\|25kg

Company Name:	Capot Chemical Co.,Ltd.
Tel:	+86-（0）57185586718; +8613336195806
Email:	sales@capot.com
Products Intro:	Product Name:7-Chloroindole-2-carboxylic acid CAS:28899-75-4 Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	Product Name:1H-Indole-2-carboxylic acid, 7-chloro- CAS:28899-75-4 Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Company Name:	Alchem Pharmtech,Inc.
Tel:	8485655694
Email:	sales@alchempharmtech.com
Products Intro:	Product Name:7-Chloro-1H-indole-2-carboxylic acid CAS:28899-75-4 Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-37206

Company Name:	CONIER CHEM AND PHARMA LIMITED
Tel:	+8618523575427
Email:	sales@conier.com
Products Intro:	Product Name:7-chloro-1H-indole-2-carboxylic acid CAS:28899-75-4 Package:100g,1kg

7-chloro-1H-indole-2-carboxylic acid manufacturers

7-chloro-1H-indole-2-carboxylic acid Basic information

Product Name:	7-chloro-1H-indole-2-carboxylic acid
Synonyms:	7-chloro-1H-indole-2-carboxylic acid(SALTDATA: FREE);7-Chloroindole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 7-chloro-;7-Chloro-1H-indole-2-carboxylic acid
CAS:	28899-75-4
MF:	C9H6ClNO2
MW:	195.6
EINECS:	249-296-5
Product Categories:
Mol File:	28899-75-4.mol

7-chloro-1H-indole-2-carboxylic acid Chemical Properties

Boiling point	449.7±25.0 °C(Predicted)
density	1.548±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	4.23±0.30(Predicted)
form	solid
Appearance	White to off-white Solid
InChI	InChI=1S/C9H6ClNO2/c10-6-3-1-2-5-4-7(9(12)13)11-8(5)6/h1-4,11H,(H,12,13)
InChIKey	NVKAHBFPKVINGE-UHFFFAOYSA-N
SMILES	N1C2=C(C=CC=C2Cl)C=C1C(O)=O

Safety Information

MSDS Information

7-chloro-1H-indole-2-carboxylic acid Usage And Synthesis

Uses	7-chloro-1H-indole-2-carboxylic acid is an important pharmaceutical intermediate compound used in the preparation of protease inhibitors.
Synthesis	A mixture of 111.5 g of 7-chloroindole-2-carboxylate in 31.25 g of 96percent sodium hydroxide in 183 ml of methanol and 183 ml of water were heated under reflux for 1 hour, cooled to 45 ° C, and 10 percent hydrochloric acid was added dropwise to a pH of 3 to 4. The mixture was sufficiently cooled to obtain 89.7 g of product as an off-white 7-chloro-1H-indole-2-carboxylic acid.
References	[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 19, p. 3957 - 3960 [2] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0060; 0063 [3] Journal of the Chemical Society, 1955, p. 3499,3502 [4] Patent: US2003/207893, 2003, A1 [5] Patent: WO2004/22061, 2004, A1. Location in patent: Page/Page column 56-57

7-chloro-1H-indole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Tag:7-chloro-1H-indole-2-carboxylic acid(28899-75-4) Related Product Information

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