5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy-

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5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy- Suppliers list
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Products Intro: Product Name:CHIKV-IN-2
CAS:2361289-44-1
Purity:98.57% Package:1mg;53USD|5mg;130USD|10mg;197USD
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Products Intro: Product Name:CHIKV-IN-2
CAS:2361289-44-1
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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CAS:2361289-44-1
Purity:98% Package:$142.9/1mg;$300.9/5mg;$480.9/10mg;$950.9/25mg;$1450.9/50mg;$2250.9/100mg;Bulk pa Remarks:98%
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Products Intro: Product Name:CHIKV-IN-2
CAS:2361289-44-1
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Products Intro: Product Name:N-(4-(2-cyanopropan-2-yl)phenyl)-3-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-carboxamide;CHIKV-IN-2
CAS:2361289-44-1
Purity:98% HPLC Package:100g;10g;5g;1g;500mg;250mg;100mg;10mg;5mg

5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy- manufacturers

  • CHIKV-IN-2
  • CHIKV-IN-2 pictures
  • $37.00
  • 2026-04-20
  • CAS:2361289-44-1
  • Purity: 98.67%
  • Supply Ability: 10g
5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy- Basic information
Product Name:5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy-
Synonyms:5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy-;N-(4-(2-cyanopropan-2-yl)phenyl)-3-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-carboxamide;CHIKV-IN-2;Dihydroorotate Dehydrogenase,CHIKV,DHODH,virus,inhibit,CHIKV IN 2,Chikungunya,Inhibitor,CHIKVIN2;CHIKV-IN-2, 10 mM in DMSO
CAS:2361289-44-1
MF:C23H26N2O2
MW:362.46
EINECS:
Product Categories:
Mol File:2361289-44-1.mol
5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy- Structure
5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy- Chemical Properties
Boiling point 504.8±50.0 °C(Predicted)
density 1.143±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (275.89 mM; Need ultrasonic)
pka13.28±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy- Usage And Synthesis
UsesCHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools[1].
Biological ActivityCHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools[1]. CHIKV-IN-2 (compound 8q) is a potent pan-alphavirus inhibitor, with EC90s of 0.85-2.5 μM for CHIKV clinical isolates and attenuated vaccine strains[1].CHIKV-IN-2 is active against alphavirus VEEV (EC90=0.40 μM) as well as flaviviruses such as West Nile Virus (WNV, EC90=0.20 μM) and Dengue Virus Strain-2 (DENV-2, EC90=0.60 μM)[1]. CHIKV-IN-2 (compound 8q) (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice[1].CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t1/2=9.9, 18.5, 18.6 h) and Cmax (642, 858, 90 ng/mL) in mice[1].CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t1/2= 2.02 h) and AUC (497 hng/mL) in mice[1].
in vivo

CHIKV-IN-2 (compound 8q) (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice[1].
CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t1/2=9.9, 18.5, 18.6 h) and Cmax (642, 858, 90 ng/mL) in mice[1].
CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t1/2= 2.02 h) and AUC (497 hng/mL) in mice[1].

Animal Model:Female and male C57BL/6 mice[1]
Dosage:80 mg/kg
Administration:I.p. twice a day for 3 days
Result:Failed to inhibit virus loads at the site of infection.
Decreased virus dissemination to other tissues.
Animal Model:Male C57BL/6 mice were challenged with CHIKV in the right footpad[1]
Dosage:1 mg/kg for i.v. and 40 mg/kg for p.o., i.p., s.c. (Pharmacokinetic Analysis)
Administration:I.v., p.o., i.p., s.c.
Result:I.v.: t1/2= 2.02 h; AUC=497 hng/mL.
P.o.: F=41%; t1/2=9.9 h; Cmax=642 ng/mL.
I.p.: F=43%; t1/2=18.5 h; Cmax=858 ng/mL.
S.c.: F=4%; t1/2=18.6 h; Cmax=90 ng/mL.
References[1]. Ahmed SK, et, al. Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. J Med Chem. 2021 Apr 22;64(8):4762-4786.
5H-Benzocycloheptene-2-carboxamide, N-[4-(1-cyano-1-methylethyl)phenyl]-6,7,8,9-tetrahydro-3-methoxy- Preparation Products And Raw materials
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