2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-

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2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- manufacturers

  • JAK3-IN-14
  • JAK3-IN-14 pictures
  • $107.00
  • 2026-07-27
  • CAS:454234-24-3
  • Purity: 99.39%
  • Supply Ability: 10g
2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Basic information
Product Name:2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-
Synonyms:2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-;JAK3-IN-14;(3Z)-5-(pyridin-3-yl)-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one;JAK3-IN-14, 10 mM in DMSO
CAS:454234-24-3
MF:C18H13N3O
MW:287.32
EINECS:
Product Categories:
Mol File:454234-24-3.mol
2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Structure
2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Chemical Properties
Boiling point 607.1±55.0 °C(Predicted)
density 1.332±0.06 g/cm3(Predicted)
pka12.26±0.20(Predicted)
form Solid
color Yellow to orange
Safety Information
MSDS Information
2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Usage And Synthesis
UsesJAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].
DefinitionChEBI: 5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one is a member of indoles.
IC 50JAK3: 38 nM (IC50); JAK2: 600 nM (IC50)
References[1] Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5633-8. DOI:10.1016/j.bmcl.2006.08.022
2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Preparation Products And Raw materials
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