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| | 2-Hydroxy-1,5-naphthyridine Basic information |
| Product Name: | 2-Hydroxy-1,5-naphthyridine | | Synonyms: | 2-Hydroxy-1,5-naphthyridine;1,5-naphthyridin-2-ol;1,5-Naphthyridin-2(1H);1H-1,5-naphthyridin-2-one;2- hydroxy-1, 5-naphthidine;1,5-Naphthyridine-2(1H)-one;1,5-Naphthyridin-2(1H)-one | | CAS: | 10261-82-2 | | MF: | C8H6N2O | | MW: | 146.15 | | EINECS: | | | Product Categories: | | | Mol File: | 10261-82-2.mol |  |
| | 2-Hydroxy-1,5-naphthyridine Chemical Properties |
| Melting point | 258 °C | | Boiling point | 391.8±42.0 °C(Predicted) | | density | 1.267±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 11.29±0.20(Predicted) | | Appearance | White to light yellow Solid |
| | 2-Hydroxy-1,5-naphthyridine Usage And Synthesis |
| Uses | 1,5-Naphthyridin-2(1H)-one is used as a reactant in the design of brain penetrant JNK inhibitors for prevention of neurodegeneration. | | Synthesis | The general procedure for the synthesis of 1,5-naphthyridin-2(1H)-one from the compound (CAS: 27017-69-2) was as follows: intermediate 2 (15.8 g) was dissolved in 6N hydrochloric acid solution (100 mL) and the reaction was stirred at 110 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The solid was dried by suction filtration. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and the pH was adjusted to 6-7 with solid sodium hydroxide. the precipitated solid was separated by filtration and dried by suction with a sintered funnel for 2 h, followed by vacuum drying at 45 °C to afford the target product 1,5-naphthyridin-2(1H)-one (14.4 g, 98% yield). [ES MS] m/z 147 (MH+). | | References | [1] Patent: EP2080761, 2009, A1. Location in patent: Page/Page column 16
[2] Patent: WO2010/81874, 2010, A1. Location in patent: Page/Page column 18 |
| | 2-Hydroxy-1,5-naphthyridine Preparation Products And Raw materials |
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