PROTAC IRAK4 degrader-3

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PROTAC IRAK4 degrader-3 Suppliers list
Company Name: Shanghai Tachizaki Biomedical Research Center  
Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Company Name: Afflon Pharmaceutical (Sichuan) Co., Ltd.  
Tel: 17336178085
Email: 1684779048@qq.com
PROTAC IRAK4 degrader-3 Basic information
Product Name:PROTAC IRAK4 degrader-3
Synonyms:PROTAC IRAK4 degrader-3
CAS:2374122-43-5
MF:C57H68FN11O8S
MW:1086.29
EINECS:
Product Categories:
Mol File:2374122-43-5.mol
PROTAC IRAK4 degrader-3 Structure
PROTAC IRAK4 degrader-3 Chemical Properties
density 1.40±0.1 g/cm3(Predicted)
pka12.36±0.46(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
PROTAC IRAK4 degrader-3 Usage And Synthesis
UsesPROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau[1].
IC 50IRAK4
References[1] Nunes J, et al. Targeting IRAK4 for Degradation with PROTACs. ACS Med Chem Lett. 2019;10(7):1081-1085. Published 2019 Jun 14. DOI:10.1021/acsmedchemlett.9b00219
PROTAC IRAK4 degrader-3 Preparation Products And Raw materials
Tag:PROTAC IRAK4 degrader-3(2374122-43-5) Related Product Information
2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]methyl]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- 2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- INDEX NAME NOT YET ASSIGNED 2-Pyridinecarboxamide, N-[2-[trans-4-[[[3-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]propyl]methylamino]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)- 2-Pyridinecarboxamide, 6-(1,1-difluoroethyl)-N-[2-[trans-4-[[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-methoxy-2H-indazol-5-yl]- 2-Pyridinecarboxamide, N-[2-[trans-4-[[4-[[trans-3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]cyclobutyl]oxy]-1-piperidinyl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-