1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-

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1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]- manufacturers

  • NMS-P953
  • NMS-P953 pictures
  • $3700.00
  • 2026-07-27
  • CAS:1403679-33-3
  • Purity:
  • Supply Ability: 10g
1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]- Basic information
Product Name:1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-
Synonyms:1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-;NMS-P953
CAS:1403679-33-3
MF:C16H11ClF3N5O
MW:381.74
EINECS:
Product Categories:
Mol File:1403679-33-3.mol
1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]- Structure
1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]- Chemical Properties
Boiling point 602.8±65.0 °C(Predicted)
density 1.519±0.06 g/cm3(Predicted)
pka11.92±0.50(Predicted)
Safety Information
MSDS Information
1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]- Usage And Synthesis
DescriptionNMS-P953 is a JAK2 inhibitor, displaying significant tumor growth inhibition in SET-2 xenograft tumor model. NMS-P953 has a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile.
UsesNMS-P953 (compound 28) is an orally active JAK2 inhibitor (IC50=0.008 μM) with antitumor activity[1].
IC 50JAK2: 0.008 μM (IC50)
References[1] Brasca M G, et al. Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2014, 22(17): 4998-5012. DOI:10.1016/j.bmc.2014.06.025
1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]- Preparation Products And Raw materials
Tag:1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-(1403679-33-3) Related Product Information
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