Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1)

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Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1) Suppliers list
Company Name: Guangdong Fengkang Synthetic Chemical Technology Co., Ltd  
Tel: 15953196022
Email: fulkare@163.com
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1) Basic information
Product Name:Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1)
Synonyms:Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1)
CAS:187587-97-9
MF:C43H78ClN
MW:644.55
EINECS:
Product Categories:
Mol File:187587-97-9.mol
Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1) Structure
Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1) Chemical Properties
solubility Acetonitrile: Slightly soluble
Chloroform: Soluble
Safety Information
MSDS Information
Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1) Usage And Synthesis
UsesSAINT-2 is a cationic lipid with gene transfection activity and is a pyridyl lipid analog. Molecular membranes prepared by SAINT-2 can interact with plasmids to form lipid complexes. After the complex is taken up by cells, the plasmid dissociates from the lipid complex under the action of DOPE and the plasmid translocates across the endosome and/or nuclear membrane. Thus, SAINT-2 effectively transfers small oligonucleotides into cells[1].
References[1] Zuhorn IS, et al. Phase behavior of cationic amphiphiles and their mixtures with helper lipid influences lipoplex shape, DNA translocation, and transfection efficiency. Biophys J. 2002 Oct;83(4):2096-108. DOI:10.1016/S0006-3495(02)73970-2
[2] I VAN DER WOUDE. Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1997, 94 4: 1160-1165. DOI: 10.1073/pnas.94.4.1160
[3] CHIEN-NENG KUO . Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis[J]. Experimental eye research, 2009, 89 5: Pages 678-685. DOI: 10.1016/j.exer.2009.06.021
[4] BERNARDINA T.F. VAN DER GUN . Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid Saint-2[J]. Journal of Controlled Release, 2007, 123 3: Pages 228-238. DOI: 10.1016/j.jconrel.2007.08.014
[5] JOANNA E. ADRIAN . Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells[J]. Journal of Controlled Release, 2010, 144 3: Pages 341-349. DOI: 10.1016/j.jconrel.2010.03.003
Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1) Preparation Products And Raw materials
Tag:Pyridinium, 1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-, chloride (1:1)(187587-97-9) Related Product Information
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