| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Ziprasidone mesylate
CAS:185021-64-1
Package:25mg/RMB 14900;100mg/RMB 24625;50mg/RMB 19420
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| Company Name: |
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
|
| Tel: |
0714-3999001 17771081808 |
| Email: |
2654977911@qq.com |
| Products Intro: |
Product Name:Ziprasidone Mesylate
CAS:185021-64-1
Purity:99% HPLC Package:10mg、25mg、50mg、100mg
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2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-, methanesulfonate (1:1) manufacturers
- Ziprasidone mesylate
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- $2140.00 / 25mg
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2026-05-11
- CAS:185021-64-1
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-, methanesulfonate (1:1) Basic information |
| | 2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-, methanesulfonate (1:1) Chemical Properties |
| | 2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-, methanesulfonate (1:1) Usage And Synthesis |
| Uses | Ziprasidone (CP-88059) mesylate is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1]. | | in vivo | Ziprasidone mesylate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3]. | Animal Model: | Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3] | | Dosage: | 20 mg/kg | | Administration: | Oral gavage; 20 mg/kg; once daily; 7 weeks | | Result: | Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001). |
| | IC 50 | Rat 5-HT2 Receptor: 0.42 nM (Ki); Rat 5-HT1A Receptor: 3.4 nM (Ki); Rat D2 Receptor: 4.8 nM (Ki) | | References | [1] H Rollema, et al. 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry. 2000 Aug 1;48(3):229-37. DOI:10.1016/s0006-3223(00)00850-7
[2] Zhi Su, et al. Block of hERG channel by ziprasidone: biophysical properties and molecular determinants. Biochem Pharmacol. 2006 Jan 12;71(3):278-86. DOI:10.1016/j.bcp.2005.10.047
[3] Subin Park, et al. The effect of ziprasidone on body weight and energy expenditure in female rats. Metabolism. 2012 Jun;61(6):787-93. DOI:10.1016/j.metabol.2011.10.011 |
| | 2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-, methanesulfonate (1:1) Preparation Products And Raw materials |
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