4-Phenylbutyric acid NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-01 |
Product Details
| Product Name: 4-Phenylbutyric acid | CAS No.: 1821-12-1 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2025/11/01 |
Product Introduction
Bioactivity
| Name | 4-Phenylbutyric acid |
| Description | 4-Phenylbutyric acid (Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. 4-Phenylbutyric acid can be used to treat urea cycle disorders. |
| In vitro | METHODS: ERp57 KO and control cells were treated with 4-Phenylbutyric acid (50 mM) and protein expression levels were detected by Immunoblot analysis. RESULTS: Levels of ER stress marker proteins BiP, Chop and IRE1 were increased in ERp57 KO cells compared to control cells, indicating higher levels of ER stress in the absence of ERp57. 50 mM 4-Phenylbutyric acid treatment was effective in ERp57 KO cells and reduced protein levels of all three ER stress markers. protein levels of all three ER stress markers. In the case of IRE1, ER stress proteins were even reduced below the levels of control cells. [1] METHODS: A549 cells and primary nasal epithelial cells were treated with 4-Phenylbutyric acid (0-20 mM) for 72 h. Cell viability was measured by MTT assay. RESULTS: Cells were examined after treatment with 4-Phenylbutyric acid concentrations ranging from 0-20 mM, and cell survival was not affected below 10 mM. [2] |
| In vivo | METHODS: To study the effects on obese mice, 4-Phenylbutyric acid (120 mg/kg) was administered intraperitoneally to KK-Ay mice fed Lieber-DeCarli diet (5% EtOH) once daily for ten days. On day 11, a single dose of EtOH (4 g/kg) was administered by gavage. RESULTS: In an obese mouse model, chronic overdose of EtOH induced massive ER stress-related oxidative stress and liver injury through dysregulation of unfolded protein responses. 4-Phenylbutyric acid ameliorated the liver injury induced by chronic addition of overdose of EtOH by decreasing ER and oxidative stress after overdose of EtOH. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (304.51 mM), Sonication is recommended. H2O : 1.64 mg/mL (9.99 mM), Sonication and heating are recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 12.5 mg/mL (76.13 mM), Solution. |
| Keywords | VirusProtease | Virus Protease | Inhibitor | inhibit | Histone deacetylases | HDAC | 4-Phenylbutyric acid | 4Phenylbutyric acid | 4-PBA | 4 Phenylbutyric acid |
| Inhibitors Related | EIDD-1931 | Phenytoin sodium | Valproic acid sodium salt | Panobinostat | Sodium 4-phenylbutyrate | Aspirin | Anthraquinone | L-Lysine | 2-Phenylethanol | L-Lysine hydrochloride | Valproic Acid | Curcumin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Miao medicine Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/25KG |
Hebei Chuanghai Biotechnology Co., Ltd
|
2024-10-31 | ||
| $5.00/1KG |
VIP2Y
|
Henan Fengda Chemical Co., Ltd
|
2024-04-16 | |
| $30.00/1kg |
Hebei Yanxi Chemical Co., Ltd.
|
2023-10-08 | ||
| $100.00/1bag |
Hebei Fengqiang Trading Co., LTD
|
2023-09-07 | ||
| $0.00/25KG |
VIP6Y
|
Sichuan Zhuoyu Yantang Technology Co., Ltd.
|
2023-07-28 | |
| $0.00/25kg |
VIP4Y
|
Shanghai Joiny Pharmaceutical Co.,LTD
|
2022-12-09 | |
| $0.00/1kg |
VIP4Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-30 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-11 | ||
| $0.10/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-01-03 | |
| $100.00/1KG |
VIP8Y
|
Career Henan Chemical Co
|
2018-07-26 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY