AGN 194310 NEW
| Price | $596 | $1710 | $2230 |
| Package | 5mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: AGN 194310 | CAS No.: 229961-45-9 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | AGN 194310 |
| Description | AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2]. |
| In vitro | AGN194310 effectively inhibits colony formation in LNCaP, PC3, and DU-145 cells with IC50 values of 16 nM, 18 nM, and 34 nM, respectively[2]. At concentrations of 50 nM and 100 nM, both alone and combined with TTNPB, AGN194310 inhibits colony formation in these cell lines[2]. Additionally, treatment with AGN194310 (1 μM for 72 hours) results in 80% apoptosis in LNCaP cells[2]. |
| In vivo | AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment significantly increases granulocyte numbers across hematopoietic compartments and the frequency of granulocyte-progenitor cells in bone marrow[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (117.77 mM), Sonication is recommended. |
| Keywords | VTP194310 | VTP 194310 | RetinoidReceptor | Retinoid Receptor | RARγ | RARβ | RARα | AGN-194310 | AGN194310 | AGN 194310 |
| Inhibitors Related | Isotretinoin | Oxybenzone | Adapalene | MSU-42011 | Retinoic acid | Tazarotene | Etodolac | ER 50891 | Acitretin | Tamibarotene | Bexarotene | TTNPB |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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