CDK8/19-IN-51 NEW
| Price | $1170 | $2158 |
| Package | 5mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: CDK8/19-IN-51 | CAS No.: 1860885-61-5 |
| Purity: 99.62% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | CDK8/19-IN-51 |
| Description | CDK8/19-IN-51 is an orally active and highly effective dual inhibitor of CDK8 and CDK19, with anticancer activity. Its IC50 values for CDK8 and CDK19 are 5.1 nM and 5.6 nM, respectively. It is used in studies of colorectal and gastric cancers. |
| In vitro | In SW620 human colorectal carcinoma cells harboring an activating APC mutation, CDK8/19-IN-51 inhibited phospho-STAT1^Ser727 with an IC50 of 17.9 nM, which serves as a biomarker of CDK8 inhibition [1]. |
| In vivo | In in vivo pharmacokinetic (PK) studies in mice and rats, CDK8/19-IN-51 exhibited moderate in vivo clearance and volume of distribution (Vd) but showed low bioavailability in mice. In an SW620 human colorectal carcinoma xenograft model, oral administration of CDK8/19-IN-51 (5 mg/kg) inhibited phospho-STAT1^Ser727 in a time-dependent manner. CDK8/19-IN-51 serves as an advanced chemical tool for further investigation of the efficacy, safety, and tolerability of dual CDK8/19 inhibitors [1]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 8.00 mg/mL (19.30 mM), Sonication is recommended. |
| Keywords | CCT-251545 analogue, Compound 51 |
| Inhibitors Related | Ribociclib | Ro-3306 | GSK 3 Inhibitor IX | Abemaciclib | Rafoxanide | AT7519 | Palbociclib monohydrochloride | CASIN | GW 441756 | Sodium Oxamate | Dinaciclib | Abemaciclib methanesulfonate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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