CCT365623 hydrochloride NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: CCT365623 hydrochloride | CAS No.: 2126136-98-7 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | CCT365623 hydrochloride |
| Description | CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF. |
| In vitro | CCT365623 inhibits LOX at approximately 5 μM in the biosensor system. CCT365623 (0-40 μM) decreases surface EGFR protein levels in a concentration-dependent manner, disrupts HTRA1 multimerization, activates [TGFβ1] signaling, suppresses MATN2 expression, and reduces EGFR surface retention and signaling. At 5 μM, CCT365623 decreases pY1068 EGFR, pAKT, and MATN2 protein levels, while increasing pSMAD2 protein levels. |
| In vivo | CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cells. CCT365623 exhibits a T1/2PO of 0.6 h and F% (oral bioavailability) of 45%. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | LOX | CCT-365623 hydrochloride | CCT-365623 Hydrochloride | CCT365623 Hydrochloride | CCT365623 hydrochloride | CCT 365623 Hydrochloride |
| Inhibitors Related | Musk ketone | Caffeic Acid | Phenidone | Hydrochlorothiazide | 1,4-Naphthoquinone | Artemisinin | Paeonol | Erlotinib | Malotilate | Pirfenidone | Gefitinib | 2,3-Butanediol |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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