Product Details
| Product Name:
Cercosporamide |
CAS No.:
131436-22-1 |
| Supply Ability:
10g |
Release date:
2025/08/21 |
Product Introduction
Bioactivity
| Name | Cercosporamide |
| Description | Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor. |
| In vitro | Cercosporamide is a broad-spectrum natural antifungal compound and a selective, highly potent fungal Pkc1 kinase inhibitor [1]. Recently, it has been shown to act as a unique Mnk inhibitor with antileukemic properties. Cercosporamide inhibits phosphorylation of eIF4E at Ser209 in AML cells, leading to potent inhibitory effects on primitive leukemic progenitors (CFU-L) from AML patients. Dose-dependent suppression of cell growth is observed in U937 cells and similar results are noted in experiments with MM6 and K562 cells [2]. |
| In vivo | Treatment with either Cercosporamide or Ara-C alone markedly inhibits xenograft growth compared to their respective controls, achieving statistical significance (P<0.011 for 10 mg/kg Cercosporamide twice-daily; P<0.006 for 20 mg/kg Cercosporamide daily; P<0.0374 for Ara-C). The combined application of Cercosporamide (10 mg/kg twice daily) with Ara-C substantially enhances efficacy beyond that of either compound used singly. Similarly, the synergy of Cercosporamide (20 mg/kg daily) with Ara-C markedly reduces tumor growth compared to both captisol (P<0.0001) and water controls (P=0.0003), albeit without significant superiority over the individual effects of either Cercosporamide (20 mg/kg) or Ara-C alone. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Pkc1 | Mnk | Cercosporamide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2020-01-18 |
United States