Product Details
| Product Name:
CHF5407 |
CAS No.:
1004312-94-0 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2025/06/18 |
Product Introduction
Bioactivity
| Name | CHF5407 |
| Description | CHF5407(SVT-47060) is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors.CHF5407 has an effect on bronchospasm and may be used in the study of respiratory disorders.CHF5407 is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors. |
| In vitro | Producing a potent (pIC50=9.0-9.6) and long-lasting (up to 24 h) inhibition of M3 receptor-mediated contractile responses to carbachol in the guinea pig isolated trachea and human isolated bronchus, CHF5407 exhibits a very slow dissociation from M3 receptors (hM3; t1/2=166 min) and markedly short-acting effects at M2 receptors (hM2; t1/2=31 min)[1]. |
| In vivo | Administered intratracheally in a single dose of 100 μl at doses of 0.1, 0.3, and 1 nmol/kg, CHF5407 exerted a dose-dependent and potent inhibition of ACh-induced bronchospasm (20 g/kg; i.v.) in guinea pigs (450-550 g), with an ED50 value of 0.15 nmol/kg[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Muscarinic M3-receptor | M3 mAChR | CHF-5407 | CHF5407 | CHF 5407 |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Clozapine N-Oxide | Pilocarpine nitrate | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$312.00/5mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-10-27 |
United States