Product Details
| Product Name:
IKs124 |
CAS No.:
199335-15-4 |
| Purity:
99.53% |
Supply Ability:
10g |
| Release date:
2025/11/10 |
Product Introduction
Bioactivity
| Name | IKs124 |
| Description | IKs124 is a KCNE2/KCNQ1 potassium channel blocker with an IC50 = 8 nM, as well as an IC50 of 370 nM and 440 nM for KCNE1 and KCNE3, respectively, and can be used to study peptic ulcers. |
| In vitro | IKs124 is a selective activator of KCNQ1/KCNE1 (IKs) potassium channels. In HEK293 cells expressing these channels, IKs124 enhanced IKs current in a dose-dependent manner from 0.1 to 10 μM, with maximal stimulation (~60%) observed within 5 minutes at 10 μM. IKs124 did not affect other potassium channels such as hERG or Kir2.1, demonstrating good selectivity[1]. |
| In vivo | In isolated guinea pig atrial preparations, IKs124 (1 μM) significantly shortened action potential duration (APD), with more pronounced effects at higher pacing frequencies. This indicates that IKs124 enhances repolarization via IKs activation and may be useful in treating arrhythmias associated with prolonged repolarization[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | IKs124 |
| Inhibitors Related | Minoxidil sulfate | Tannic acid | Cromolyn sodium | Hydrochlorothiazide | (±)-Naringenin | Tolbutamide | Halothane | Ursodeoxycholic acid | Cloperastine hydrochloride | Chlorzoxazone | Nifedipine | Indapamide |
| Related Compound Libraries | Bioactive Compounds Library Max |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
-
CAS:1622140-49-1
$193.00 / 1mg
-
CAS:122937-55-7
$2500.00 / 100mg
-
CAS:1332329-27-7
$1520.00 / 25mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States