JNK3 inhibitor-3 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: JNK3 inhibitor-3 | CAS No.: 2873465-25-7 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | JNK3 inhibitor-3 |
| Description | JNK3 Inhibitor-3 (compound 15g) is a selective, blood-brain barrier permeable, and orally active inhibitor of c-Jun N-terminal kinase 3 (JNK3) with IC50 values of 147.8 nM, 44.0 nM, and 4.1 nM against JNK1, JNK2, and JNK3, respectively. This compound has been shown to significantly enhance memory in mouse models of dementia and is utilized in Alzheimer's disease research [1]. |
| In vitro | JNK3 inhibitor-3, at concentrations ranging from 0 to 10 μM, exhibits inhibitory effects on JNK1, JNK2, and JNK3, with respective IC50s of 147.8, 44.0, and 4.1 nM. Additionally, at a 20 μM concentration and exposure times of 24 and 48 hours, the compound displays neuroprotective properties in vitro [1]. |
| In vivo | JNK3 inhibitor-3, administered orally at doses of 30 and 60 mg/kg daily for 2 to 2.2 months, enhances memory in the 3xTg mouse model of dementia [1]. Regarding its pharmacokinetic properties in rats, after intravenous (IV) administration of 1 mg/kg, the area under the curve (AUC) is 1085.24 hr•ng/mL, and after oral (PO) administration of 3 mg/kg, the AUC is 2806.77 hr•ng/mL. The maximum concentration (Cmax) following IV administration is 1238.85 ng/mL, occurring at a peak time (Tmax) of 0.67 hours. The half-life (T1/2) is 0.36 hours IV and 1.14 hours PO, with a bioavailability (BA) of 86.21% [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Urolithin B | Astragaloside IV | SKLB-163 | SP600125 | (-)-Bornyl acetate | Tanzisertib | Anisomycin | SR-3306 | (E)-Ferulic acid methyl ester | Bentamapimod | Ginsenoside Re | TCS JNK 5a |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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