L-arginine NEW

L-arginine

Modify Date: 2025-08-20 18:11:21

L-arginine structure	Common Name	L-arginine
	CAS Number	74-79-3	Molecular Weight	174.201
	Density	1.5±0.1 g/cm3	Boiling Point	367.6±52.0 °C at 760 mmHg
	Molecular Formula	C6H14N4O2	Melting Point	222 °C (dec.)(lit.)
	MSDS	ChineseUSA	Flash Point	176.1±30.7 °C

Purity		Quantity		Budget		Inquiry

Use of L-arginine L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.

• Properties

• Articles396

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 Names

Name	L-arginine
Synonym	More Synonyms

 L-arginine Biological Activity

Description	L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Natural Products >> Others Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

 Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	367.6±52.0 °C at 760 mmHg
Melting Point	222 °C (dec.)(lit.)
Molecular Formula	C6H14N4O2
Molecular Weight	174.201
Flash Point	176.1±30.7 °C
Exact Mass	174.111679
PSA	125.22000
LogP	-1.79
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.601
Water Solubility	148.7 g/L (20 ºC)

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