N-Nitroso Tadalafil NEW

 N-Nitroso Tadalafil

Product Information

• Product Code: T007086

• English Name: N-Nitroso Tadalafil

• English Alias: (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-7-nitroso-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione

• CAS No.: Not provided

• Molecular Formula: C₂₂H₁₈N₄O₅

• Molecular Weight: 418.40

Advantages

• As a nitroso derivative impurity of Tadalafil, it is used for pharmaceutical quality control and safety assessment to ensure that the content of such impurities in Tadalafil API and formulations meets the requirements of pharmacopoeias and regulations.

• The nitroso group (-NO) in the structure may serve as a characteristic impurity for impurity profile analysis, helping pharmaceutical companies optimize production processes and reduce potential genotoxic risks.

Applications

• Drug R&D and Quality Control: As a reference standard for qualitative and quantitative analysis of impurities in Tadalafil-related drugs, such as the development and validation of HPLC, LC-MS and other detection methods.

• Safety Evaluation: Nitroso compounds may have potential toxicity. The study of this impurity can assist in evaluating the safety of Tadalafil products and provide data support for drug registration and regulatory submission.

Background Description

Research Status

• Analytical Method Research: The current detection of nitroso impurities mostly uses high-sensitivity chromatography-mass spectrometry technology, with the focus on optimizing the limit of detection and limit of quantification to meet the regulatory requirements for trace impurities.

• Toxicity Risk Assessment: Some studies focus on the potential genotoxicity of such impurities, and establish safe exposure limits through toxicological experiments to provide a basis for pharmaceutical impurity control standards.

• Process Control: The pharmaceutical industry is reducing the formation of nitroso impurities by optimizing synthetic routes and improving purification processes. Related impurity reference standards play a key role in process validation.

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!