SKF-83566 NEW
| Price | $83 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-31 |
Product Details
| Product Name: SKF-83566 | CAS No.: 99295-33-7 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2025/10/31 |
Product Introduction
Bioactivity
| Name | SKF-83566 |
| Description | SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
| In vitro | SKF-83566 caused a concentration-dependent increase in peak single-pulse evoked extracellular DA concentration, with a maximum increase of 65% in 5 μM SKF-83566.?This was accompanied by a concentration-dependent increase in extracellular DA concentration clearance time.?Both effects were occluded by nomifensine (1 μM), a dopamine transporter (DAT) inhibitor, suggesting that SKF-83566 acted via the DAT.?Tested this by examining [(3)H]DA uptake into LLc-PK cells expressing rat DAT, and confirmed that SKF-83566 is a competitive DAT inhibitor with an IC(50) of 5.7 μM.?Binding studies with [(3)H]CFT, a cocaine analog, showed even more potent action of SKF-83566 at the DAT cocaine binding site (IC(50) = 0.51 μM)[1]. |
| In vivo | The facilitation induced by nicotine and cocaine can be blocked by oral administration of the dopamine D1/D5 receptor antagonist (SKF 83566) |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mM, Sonication is recommended. |
| Keywords | SKF-83566 | SKF83566 | SKF 83566 | Serotonin Receptor | parkinson's disease | nicotine craving | Inhibitor | inhibit | hippocampus | drug-related | dorsal striatum | DopamineReceptor | dopamine uptake | Dopamine Receptor | Dopamine | dentate gyrus | D5 | D1 | associative memory | Adenylyl cyclase | Adenylate Cyclase | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT2 | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Alverine citrate | Dapoxetine hydrochloride | Urethane | Ribavirin | Octopamine hydrochloride | D-Menthol | Choline chloride | Propoxur | Oxolinic acid | Trazodone hydrochloride |
| Related Compound Libraries | Anti-Parkinson's Disease Compound Library | Anti-Hypertension Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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