ZYZ-488 NEW
| Price | $297 | $987 | $1360 |
| Package | 5mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-09-29 |
Product Details
| Product Name: ZYZ-488 | CAS No.: 1470302-79-4 |
| Purity: 99.04% | Supply Ability: 10g |
| Release date: 2025/09/29 |
Product Introduction
Bioactivity
| Name | ZYZ-488 |
| Description | ZYZ-488 is an Apoptotic Protease-Activating Factor 1 (Apaf-1) inhibitor that inhibits the activation of procaspase-9 and procaspase-3. It can be used to study cardiovascular diseases. |
| In vitro | ZYZ-488 is a novel inhibitor of apoptotic protease activator 1 (Apaf-1). The main mechanism is that ZYZ-488 binds directly to Apaf-1, thus blocking the recruitment of procaspase-9 by Apaf-1. [1] |
| In vivo | Intramuscular injection of ZYZ-488 (33.9 mg/kg or 67.8 mg/kg) in mice reduced the MI-induced increase in left ventricular volume and reduced the thickness of the ventricular wall. ZYZ-488 preserves cardiac function in a dose-dependent manner. [1] [2] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 80 mg/mL (164.12 mM), Sonication is recommended. DMSO : 180 mg/mL (369.26 mM), Sonication is recommended. |
| Keywords | ZYZ-488 | ZYZ 488 | Apoptotic protease activating factor-1 |
| Inhibitors Related | Taurodeoxycholic acid | Allethrin | SKLB-163 | Z-VAD(OMe)-FMK | Fenbufen | Cystamine | Tauroursodeoxycholate sodium | (Iso)-Z-VAD(OMe)-FMK | CIL62 | Tauroursodeoxycholate | Allicin | PAC-1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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