马来酸氨氯地平（GMP)

马来酸氨氯地平

CAS号：
88150-47-4

产品介绍：
马来酸氨氯地平是一种钙通道阻断剂，能有效的治疗心绞痛和高血压。它能抑制细胞外钙离子跨心肌和血管平滑肌细胞膜的涌入，导致细胞内钙离子减少，从而抑制心肌平滑肌细胞的收缩过程，引起冠状动脉及全身动脉扩张，增加氧气输送到心肌组织，降低总外周阻力，降低全身血压，减少负荷。另一种可能的机制是氨氯地平引起的pH值连续增高，从而抑制血管平滑肌的碳酸酐酶I的活力，这可能与通过钙离子通道的胞内钙离子内流有关的活动。

先声药业的帕洛诺司琼原料药：
先声药业的马来酸氨氯地平原料药和制剂成功通过了SFDA的GMP认证。制剂商品名为“宁立平”。

一些产品参数
产品标准 CP
性    状 类白色结晶性粉末
熔    点 173-174℃（分解）
干燥失重 0.2%
炽灼残渣 小于0.2%
重 金 属 小于20ppm
含量      99.9%
包装规格 20kg/桶

关键词:  马来酸氨氯地平,氨氯地平, 88150-47-4，络活喜

Amlodipine Maleate

CAS:
88150-47-4

Introduction:
Amlodipine Maleate is a calcium channel blocking agent，and It is effective in the treatment of angina pectoris and hypertension. It inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity with consecutive pH increase which may be involved in intracelluar calcium influx through calcium channels.

Simcere's Amlodipine Maleate API:
Simcere’s API and preparations of Amlodipine Maleate are both successfully passed and received SFDA GMP certification. Its brand name is Ningliping.

Some inspection data
Specification     CP
Properties       Almost white crystalline powder
Meeting Point     173~174℃(Decomposed)
Loss on drying    0.2 %
Residue on ignition 0.2% max
Heavy metals     20 ppm max
Assay            99.9 %
Package          20 kg/drum
 
Keyword: Amlodipine Maleate, Amlodipine, 88150-47-4，Norvasc