非那西丁

phenacetin uses

Phenacetin is a non-opioid analgesic compound that inhibits COX-3 activity and has anti-inflammatory activity.

SIGNAL :   

                 GHS07, GHS08

Preparation of phenacetin

(1) It is obtained by acetylation of p-aminophenethyl ether. The mixture of benzene, acetic anhydride and p-aminophenethyl ether was heated and azeotroped on an oil bath for 4h. After the reaction was completed, the reactant was cooled, that is, phenatine was precipitated, filtered, washed with cold benzene, and dried, and the yield was the theoretical amount. 86%.

(2) Obtained by the action of acetamidophenol and sodium ethoxide: first, add p-acetamidophenol to sodium ethoxide, then slowly add iodoethane, heat to reflux for 1 h, cool, filter, and the obtained crude product is dissolved in ethanol, Filtration, the filtrate is diluted with hot water, then cooled, filtered and dried to obtain the finished product, and the yield is 80% of the theoretical amount. The first method can also use acetic acid instead of benzene as a solvent, and the process is as follows. Heat 40% dilute acetic acid to boiling, put in p-aminophenethyl ether, evaporate the water, add glacial acetic acid when the temperature rises to 150°C, reflux for 1 hour, continue to steam, and take a sample to measure free aminobenzene when the temperature rises above 150°C Diethyl ether, add acetic anhydride according to the amount of residual amino phenethyl ether, reflux reaction for 0.5h, check the end point, decompress after passing the qualification, recover acetic acid until the amino content is below 0.046, and the acid content is below 0.2%, the reaction liquid is poured into the thermal refining mother liquor, The temperature was lowered to 40°C with stirring, and filtered to obtain crude phenacetin. Refining, adding boiling water or refining mother liquor to the crude phenacetin, heating and stirring to dissolve, filtering, adjusting the filtrate to pH=4.5-4.7 with acid, adding activated carbon and sodium thiosulfate, stirring and decolorizing, filtering, cooling and crystallization of the filtrate, filtration, air flow Dry, get phenacetin.

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Shengzhikai Biotech is one of the China's leading high-performance pharmaceutical intermediate products suppliers. It covers 4 popular research fields including pharmaceutical intermediate ，plant extract ,chemical reagent and chemical intermediate .Existing compounds are continuously expanded to meet the latest research needs. As an researcher and manufacturer of pharmaceutical intermediate , Shengzhikai has good purity, stability activity. Our core philosophy is "guarantee the quality of each product" and is committed to providing comprehensive research materials and reliable produ