Name: MO-I-500
CAS#: 1585219-04-0
Chemical Formula: C12H12ClNO5S
Exact Mass: 317.0125
Molecular Weight: 317.74
Elemental Analysis: C, 45.36; H, 3.81; Cl, 11.16; N, 4.41; O, 25.18; S, 10.09
Description: MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO in vitro), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.
IUPAC/Chemical Name: N-(3,4-Dihydroxy-5-(4-chlorophenyl)-2-furanyl)ethanesulfonamide
InChi Key: WWHUSZQHRUNRSB-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H12ClNO5S/c1-2-20(17,18)14-12-10(16)9(15)11(19-12)7-3-5-8(13)6-4-7/h3-6,14-16H,2H2,1H3
SMILES Code: CCS(=O)(NC1=C(O)C(O)=C(C2=CC=C(Cl)C=C2)O1)=O
Appearance: Solid powder
关键字： 1585219-04-0;MO-I-500;
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