Name: PRLX-93936
CAS#: 903499-49-0
Chemical Formula: C21H24N4O2
Exact Mass: 364.1899
Molecular Weight: 364.449
Elemental Analysis: C, 69.21; H, 6.64; N, 15.37; O, 8.78
Description: PRLX 93936 is a structural analogue of erastin with potential antineoplastic activity. Erastin analogue PRLX 93936 appears to inhibit mitochondrial outer membrane protein VDACs (voltage-dependent anion channels) 2 and 3, resulting in an oxidative, non-apoptotic cell death. Erastin analogue PRLX 93936 exhibits greater lethality in cell lines harboring mutations in the GTPase protein oncogenes HRAS and KRAS or the serine-threonine protein kinase oncogene BRAF than in non-tumorigenic cell lines. VDACs 2 and 3 are up-regulated in a wide variety of tumor cell lines.
IUPAC/Chemical Name: 3-(2-ethoxyphenyl)-2-(piperazin-1-ylmethyl)quinazolin-4(3H)-one
InChi Key: OBWOSMGNXYUDFB-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H24N4O2/c1-2-27-19-10-6-5-9-18(19)25-20(15-24-13-11-22-12-14-24)23-17-8-4-3-7-16(17)21(25)26/h3-10,22H,2,11-15H2,1H3
SMILES Code: O=C1N(C2=CC=CC=C2OCC)C(CN3CCNCC3)=NC4=C1C=CC=C4
Appearance: Solid powder
关键字： 903499-49-0;PRLX-93936;
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