Description: Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis. In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally. Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively). Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.
Name: Albendazole-d7
CAS#: 1287076-43-0
Chemical Formula: C12H8D7N3O2S
Exact Mass: 272.1324
Molecular Weight: 272.3737
Elemental Analysis: C, 52.92; H, 8.14; N, 15.43; O, 11.75; S, 11.77
Synonym: Albendazole-d7; Albendazole d7;
IUPAC/Chemical Name: methyl (5-((propyl-d7)thio)-1H-benzo[d]imidazol-2-yl)carbamate
InChi Key: HXHWSAZORRCQMX-JOMZKNQJSA-N
InChi Code: InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)/i1D3,3D2,6D2
SMILES Code: COC(NC1=NC2=CC(SC([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])=CC=C2N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
关键字： 1287076-43-0;Albendazole-d7;
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