A-FABP抑制剂| ALBP抑制剂|脂肪细胞FABP抑制剂

中文名称

A-FABP抑制剂| ALBP抑制剂|脂肪细胞FABP抑制剂| BMS 309403 |脂肪酸结合蛋白4抑制剂| aP2抑制剂；2-[[[2'-（5-乙基-3,4-二苯基-1H-吡唑-1-基）] [1,1'-联苯基] -3-基]氧基]-乙酸

英文名字

A-FABP Inhibitor|ALBP Inhibitor|Adipocyte FABP Inhibitor|BMS 309403|Fatty Acid Binding Protein 4 Inhibitor|aP2 Inhibitor; 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid

供应商

开曼生物

产品货号

10010206-10

背景资料

Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP.{25740} FABP4 inhibitor is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki is = 250 and 350 nM, respectively).{25745} FABP4 inhibitor is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E.{14840,25741} It also protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.{14840,25744} FABP4 dose-dependently suppresses the release of MCP-1 from macrophages.{25740,25744}

产品描述

A cell-permeable, potent inhibitor of FABP4 (Ki is = 250 a nd 350 nM, respectively); reduces atherosclerosis in mice lacking ApoE and protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice

保存建议

建议您在收到开曼生物品牌的FABP4 Inhibitor (10 mg)产品后置于-20度保存，产品有效期为730天.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体