N- [1-（1-氧丙基）-4-哌啶基] -N'-[4-（三氟甲氧基）苯基）-脲

中文名称

N- [1-（1-氧丙基）-4-哌啶基] -N'-[4-（三氟甲氧基）苯基）-脲

英文名字

N-[1-(1-oxopropyl)-4-piperidinyl]-N

供应商

开曼生物

产品货号

11120-10

背景资料

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively).{18630} The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.{18630,20116}

产品描述

A potent inhibitor of both human and mouse soluble epoxide hydrolase (IC50 = 3.7 and 2.8 nM, respectively); has superior pharmacokinetics compared to the 1-adamantylurea based inhibitors, like AUDA

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