产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Boceprevir-d9 | 500μg | 1256751-11-7 | EY-Y0163982 |
Cas No.1256751-11-7
别名 N/A
化学名 N/A
分子式 C27H36D9N5O5
分子量 528.7
溶解度 DMSO: Soluble,Methanol: Soluble
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Boceprevir-d9 is intended for use as an internal standard for the quantification of boceprevir by GC- or LC-MS. Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).1 Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).2 It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 μM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 μM).3 Formulations containing boceprevir have been used in the treatment of HCV.
1.Malcolm, B.A., Liu, R., Lahser, F., et al.SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cellsAntimicrob. Agents Chemother.50(3)1013-1020(2006) 2.Maren, T.H.Carbonic anhydrase: Chemistry, physiology, and inhibitionPhysiol. Rev.47(4)595-781(1967) 3.Ma, C., Sacco, M.D., Hurst, B., et al.Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaseCell Res.30(8)678-692(2020)
关键字： 1256751-11-7;C27H36D9N5O5;Boceprevir-d9;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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