产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Cyclo(his-pro) (Cyclo(histidyl-proline)) | 10mM*1mLinWater 25mg 50mg 100mg | 53109-32-3 | EY-Y0164646 |
Cas No.53109-32-3
别名 N/A
化学名 N/A
分子式 C11H14N4O2
分子量 234.25
溶解度 H2O : ≥ 30 mg/mL (128.07 mM)
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Cyclo(His-Pro) is a cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(His-Pro) could inhibit NF-κB nuclear accumulation.
Cyclo(His-Pro) is a cyclic dipeptide derived from the hydrolytic removal of the amino-terminal pyroglutamic acid residue of the hypothalamic thyrotropin-releasing hormone. Cyclo(His-Pro) is ubiquitous in the central nervous system and is a key substrate of organic cation transporters, which are strongly linked to neuroprotection. The cyclic dipeptide can also cross the brain-blood-barrier and, once in the brain, can affect diverse inflammatory and stress responses by modifying the Nrf2-NF-κB signaling axis[1]. Cyclo(His-Pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway[2].
Mice that receives cyclo(His-Pro) pre-treatment shows a significant decrease in the oedematogenic response, confirming that the cyclic dipeptide can exert anti-inflammatory effect[2]. Cyclo(His-Pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, cyclo(His-Pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress[3].
[1]. Grottelli S, et al. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332. [2]. Minelli A, et al. Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44(3):525-35. [3]. Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo(His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.
关键字： 53109-32-3;C11H14N4O2;Cyclo(his-pro) (Cycl;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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