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Description
Aducanumab (brand name: Aduhelm) is an amyloid beta-directed monoclonal antibody that targets amyloid beta in the brains of people with Alzheimer’s to reduce its buildup. Aducanumab is a monoclonal antibody (a protein that helps your immune system target other proteins), and it is designed to help your body remove something called amyloid beta from the brain. Amyloid beta is an important protein involved in the progression of Alzheimer’s disease. Aducanumab is given intravenously (infused through a vein) monthly. Aducanumab does not cure Alzheimer’s disease, but one (of two) large clinical studies suggests that aducanumab may slow the progression of the earliest symptoms of Alzheimer’s disease.
Catalog No.
DHC12504
Host species
Homo sapiens
Species reactivity
Human
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Concentration
2.13 mg/ml
Purity
>95%
Clonality
Monoclonal
Isotype
IgG1-kappa
Applications
Research Grade Biosimilar
Target
AICD-57, A4, Beta-CTF, Protease nexin-II, Gamma-CTF(50), ABPP, S-APP-beta, APP, Abeta40, Abeta42, AID(59), Amyloid intracellular domain 59, AID(57), S-APP-alpha, Gamma-CTF(59), Beta-secretase C-terminal fragment, Amyloid-beta precursor protein, Amyloid precursor protein, Beta-APP42, PreA4, Alzheimer disease amyloid protein, APPI, PN-II, AICD-59, Alpha-secretase C-terminal fragment, Amyloid-beta A4 protein, Amyloid intracellular domain 57, CVAP, Amyloid intracellular domain 50, Beta-APP40, AD1, Cerebral vascular amyloid peptide, AID(50), Alpha-CTF, Gamma-CTF(57), AICD-50
Purification
Protein A or G purified from cell culture supernatant.
Endotoxin level
Please contact with the lab for this information.
Expression system
XtenCHO
Accession
P05067
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Alternative Names
BART, BIIB-037, CAS: 1384260-65-4
Note
For research use only. Not suitable for clinical or therapeutic use.
关键字: Aducanumab;阿度努单抗;1384260-65-4;AICD-57, A4;APP, Abeta40;
武汉佰乐博生物(Biolab Reagents)始创于 2021 年,核心创始团队由五位毕业于武汉大学、华中科技大学、华中农业大学等知名高校的生命科学领域顶尖研究者组成。团队成员均深耕行业二十载,积淀了深厚的产品开发实力与成熟的技术应用经验,为企业发展筑牢核心技术根基。
佰乐博生物是国家高新技术企业、国家科技型中小企业,技术实力获权威认可;同时通过 ISO9001 质量管理体系、ISO13485 医疗器械质量管理体系双认证,以标准化、规范化的品控体系,筑牢产品品质基石。公司依托全球领先的技术平台,专注于高品质生物试剂的全球化开发与整合,与法国 AntibodySystem 品牌达成深度战略合作,系其在亚洲的独家授权合作伙伴以及生工生物KleanAB品牌的代理商。目前已构建起近 60000 种生命科学试剂的丰富产品矩阵,核心产品涵盖蛋白、抗体、试剂盒三大品类,重点覆盖肿瘤、神经系统等疾病研究热门领域,可全维度满足各类科研实验的多元需求。
自成立以来,佰乐博生物始终秉持初心,致力于为广大生命科学科研工作者、生物医药工业客户提供专业、全面、可靠的试剂产品与技术支持,以优质科研工具赋能科研探索,助力生命科学研究领域实现创新发展与深度突破。